Adaptive biomaterials through mechano-modulating bacteria

The integration of living cells into biomaterials enables the development of adaptive materials by leveraging the sophisticated sensing and production capabilities of cells. This project employs synthetic biology to engineer E. coli with genetically encoded sense-process-response functionalities, allowing them to modulate the matrix material in response to mechanical stress. By utilizing 3D bioprinting, hydrogel modification and biochemical transduction mechanisms, we aim to create self-reinforcing and adaptive biomaterials, advancing both our understanding of engineered living materials (ELMs) and their potential applications in novel additive manufacturing paradigms.